Presentations

Presentations

View materials from past presentations below

Surface-eroding Elastomer Exhibits Zero-order Release in Highly Loaded LAIs Show: American Association of Pharmaceutical 2019 PharmSci 360
Date: 11/04/2019 (Presenter: Carissa Smoot, Scientist II, Secant Group)

Commonly used materials for long-acting implantables comprise non-biodegradable polymers that rely on diffusion-mediated drug release. These LAIs lack the ability to achieve controlled release kinetics for multi-month therapies that require high drug loadings. Surface-eroding biodegradables such as elastomeric poly(glycerol sebacate) (PGS) combined with urethane (PGSU) offer a superior polymeric delivery system able to provide zero-order release at high drug loadings over many months. Download
Surface-eroding Elastomer Exhibits Zero-order Release in Highly Loaded LAIs
Methods for Dissolution Testing of Surface-eroding Long-acting Implantables Show: American Association of Pharmaceutical 2019 PharmSci 360
Date: 11/05/2019 (Presenter: Dennis Shull, Associate Scientist, Secant Group)

Surface-eroding polymers are ideal for long-acting implantable due to their ability to provide long-term sustained release based on degradation. When the polymer is non-swellable and impermeable to water, this allows for zero-order release rates dependent on the rate of polymer surface degradation. In this work, in vitro dissolution testing of caffeine-loaded poly(glycerol sebacate) urethane (PGSU) implantable rods is investigated using a USP IV flow-through cell apparatus. Download
Methods for Dissolution Testing of Surface-eroding Long-acting Implantables
Next-generation Long-acting Implantables using Surface-eroding Elastomers Show: 2019 Controlled Release Society Annual Meeting & Exposition
Date: 07/23/2019 (Presenter: Stephanie Reed, PhD, Technical Manager, New Product Development, Secant Group)

Poly(glycerol sebacate) (PGS) (Regenerez®, Secant Group) is a synthetic polyol resin that can be crosslinked using urethane chemistry to create poly(glycerol sebacate) urethane (PGSU). PGSU is elastomeric, water impermeable, shelf-life stable, biocompatible, and biodegradable via surface erosion. PGSU ultimately offers many advantages over other polymers for long-acting implantables (LAIs), particularly for high-loading, long-duration implants that are gaining interest in the pharmaceutical industry. Download
Next-generation Long-acting Implantables using Surface-eroding Elastomers
Histological and Biomechanical Evaluation of Braided Tissue Engineered Arterial Grafts in a Mouse Model Show: International Symposium for Applied Cardiovascular Biology and Vascular Tissue Engineering
Date: 06/19/2019 (Presenter: Nationwide Children's Hospital)

Tissue-engineered arterial grafts (TEAGs) are designed from biodegradable materials capable of forming a neoartery of autologous tissue that can grow and remodel within the body. Textile braiding techniques have the potential to aid in the creation of compliant TEAGs with tunable mechanical properties. In this work, TEAGs were fabricated from braided polyglycolic acid fibers with or without poly(glycerol sebacate) coating. Download
Histological and Biomechanical Evaluation of Braided Tissue Engineered Arterial Grafts in a Mouse Model