Presentations

Presentations

View materials from past presentations below

Long-acting Implantables Using Surface-eroding Elastomers Sustain Zero-order, Multi-month Release Show: 3rd Long-acting Injectables and Implantables Conference
Date: 02/06/20 (Presenters: Stephanie Reed, PhD, Director, Advanced Biomaterials Development, New Product Development, Secant Group; Carissa Smoot, Scientist II, Secant Group)

Secant Group's Hydralese™ (PGSU) (poly(glycerol sebacate) urethane) is a synthetic biodegradable elastomer for controlled drug release. Hydralese (PGSU) offers many advantages over other polymers for long-acting implantables, particularly for high-loading, long-duration implants that are gaining interest in the pharmaceutical industry. Download
Surface-eroding Elastomer Exhibits Zero-order Release in Highly Loaded LAIs Show: AAPS 2019 PharmSci 360
Date: 11/04/2019 (Presenter: Carissa Smoot, Scientist II, Secant Group)

Commonly used non-biodegradable polymers used for long-acting implantables (LAI) lack the ability to achieve controlled release kinetics for multi-month therapies that require high drug loadings. Surface-eroding biodegradables such as Secant Group's Hydralese™ (PGSU) (poly(glycerol sebacate) urethane), a synthetic biodegradable elastomer for controlled drug release, offer a superior polymeric delivery system able to provide zero-order release at high drug loadings over many months. Download
Methods for Dissolution Testing of Surface-eroding Long-acting Implantables Show: AAPS 2019 PharmSci 360
Date: 11/05/2019 (Presenter: Dennis Shull, Associate Scientist, Secant Group)

Surface-eroding polymers are ideal for long-acting implantables due to their ability to provide long-term sustained release based on degradation. This work investigates in vitro dissolution testing of caffeine-loaded implanted rods made of poly(glycerol sebacate) urethane, also known as Hydralese™ (PGSU) (Secant Group), using a USP IV flow-through cell apparatus. Hydralese (PGSU) is a synthetic biodegradable elastomer for controlled drug release capable of delivering sustained high drug loadings over a multi-month time period. Download
Next-generation Long-acting Implantables using Surface-eroding Elastomers Show: 2019 Controlled Release Society Annual Meeting & Exposition
Date: 07/23/2019 (Presenter: Stephanie Reed, PhD, Director, Advanced Biomaterials Development, New Product Development, Secant Group)

Secant Group's Hydralese™ (PGSU) (poly(glycerol sebacate) urethane) is a synthetic biodegradable elastomer for controlled drug release. PGSU is elastomeric, water impermeable, shelf-life stable, biocompatible, and biodegradable via surface erosion. Hydralese (PGSU) ultimately offers many advantages over other polymers for long-acting implantables (LAIs), particularly for high-loading, long-duration implants that are gaining interest in the pharmaceutical industry. Download
Histological and Biomechanical Evaluation of Braided Tissue Engineered Arterial Grafts in a Mouse Model Show: International Symposium for Applied Cardiovascular Biology and Vascular Tissue Engineering
Date: 06/19/2019 (Presenter: Nationwide Children's Hospital)

Tissue-engineered arterial grafts (TEAGs) are designed from biodegradable materials capable of forming a neoartery of autologous tissue that can grow and remodel within the body. Textile braiding techniques have the potential to aid in the creation of compliant TEAGs with tunable mechanical properties. In this work, TEAGs were fabricated from braided polyglycolic acid fibers with or without poly(glycerol sebacate) coating. Download