Zero-order Release of Hydrophilic Drugs at High Loadings Using Novel Biodegradable Elastomer Hydralese™ (PGSU)
Show: AAPS 2020 PharmSci 360
Date: 10/26/20 (Presenters: Stephanie Reed, PhD, Director, Advanced Biomaterials Development, New Product Development, Secant Group; Dennis Shull, BS, Associate Scientist II, Secant Group; Carissa Smoot, BS, Scientist II, Secant Group)
Secant Group’s Hydralese™ (PGSU) (poly(glycerol sebacate) urethane) provides an attractive drug delivery system due to its surface-erosion release mechanism, which allows for near zero-order release kinetics, even at high hydrophilic drug loadings. Hydralese (PGSU) is also highly flexible, water impermeable, shelf-stable, and biocompatible.
Download