Bioresorbable Resin

person using tweezers to hold up mesh in petri dish

Secant Group works to advance regenerative medicine that transforms lives. Regenerez®, a bioresorbable elastomer from Secant Group, is made from polyglycerol sebacate.  It is synthesized via a two-step polycondensation reaction between glycerol and sebacic acid. The polyglycerol sebacate polymer (PGS) can be cured to the desired level of cross-linking, enabling the tuning of physical properties that range from an elastomer to a thermoset.1  Its flexibility and inherent elastomeric properties offer limitless possibilities for scale-up production for a variety of in vivo applications - cardiovascular, orthopedics, neurovascular and tissue engineering.
Secant Medical Regenerez Mold Secant Medical Engineer Holding Bioresorbable Elastomer Resin
Key features & benefits of Regenerez:
  • Bioresorbable
  • Comprised of naturally occurring metabolites (glycerol and sebacic acid)
  • Tunable mechanical properties
  • Versatile platform for further modification
  • Closely simulates modulus of human tissue
  • Enables healing without harmful immune response

Cited in more than 400 in vivo and in vitro studies, application areas for Regenerez include2:
  • Vascular grafts3
  • Orthopedics (For example, bone regeneration)4
  • Soft tissue engineering5
  • Preventing visceroparietal peritoneal adhesions6
  • Neurovascular (For example, bridging neural defects)7
  • Cartilage
1. Wang, Y., Ameer, G., and Langer, R. (2010). U.S. Patent No. 7,722,894. Washington, DC: U.S. Patent and Trademark Office.

2. Rai, R., Tallawi, M., Grigore, A., and Boccaccini, A. (2012). Synthesis, properties and biomedical applications of poly(glycerol sebacate) (PGS): A review. Progress in Polymer Science, 37 (8), 1051-1078.

3. Wu, W., Allen R.A., and Wang, Y. (2012). Fast-degrading elastomer enables rapid remodeling of a cell-free synthetic graft into a neoartery.  Nature Medicine, 18 (7), 1148-1153.

4. Zaky, S.H., et al. (2013). Poly(glycerol sebacate) elastomer: A novel material for mechanically loaded bone regeneration. Tissue Engineering Part A, In press.

5. Chen, Q.Z., Liang, S.L., Wang, J., and Simon, G.P. (2011). Manipulation of mechanical compliance of elastomeric PGS by incorporation of halloysite nanotubes for soft tissue engineering applications. Journal of the Mechanical Behavior of Biomedical Materials, 4 (8), 1805-1818.

6. Vacanti, J.P., et al. (2009). Poly(glycerol sebacate) films prevent ostoperative adhesions and allow laparoscopic placement. Surgery, 146 (3), 490-497.

7. Langer, R.S., et al. (2005). Biocompatibility analysis of poly(glycerol sebacate) as a nerve guide material. Biomaterials, 26 (27), 5454-5464.